History Of Dental Pulp Stem Cells - 3377 Words

Introduction Regeneration of tissues to replace diseased, missing and traumatized dentin/pulp emerges from recent progress in stem cell and tissue engineering research. Dental pulp stem cells (DPSCs) are considered a promising population of cells in regenerative dentistry and have been shown to produce dentin/pulp-like tissues following implantation in vivo (Gronthos et al., 2000; Gronthos et al., 2002; Shi et al., 2001). Importantly, DPSCs reside in the microvasculature region of the dental pulp and interact with perivascular cells (Shi and Gronthos, 2003). Therefore, endothelial cells could be a major source of modulators of pulp-dentin development and angiogenesis. We recently showed that co-culture of human umbilical vein endothelial cells (HUVECs) with DPSCs enhances osteo/odontogenic differentiation and angiogenesis in monolayer cultures (Dissanayaka et al., 2012). However, the interactions of these two cells in angiogenesis and pulp-like tissue regeneration in vivo remain unknown. Shaping functional dentin/pulp complex from monodispersed expanded cell cultures is an ongoing challenge. Tissue engineers have thus mostly relied on biomaterials/scaffolds in which cells can grow and differentiate. Several reports have shown that dental stem cells being seeded onto a matrix scaffold and transplanted in vivo form a new tissue similar to that of the native pulp (Cordeiro et al., 2008; Rosa et al., 2013). However, none of the scaffolds described so far has all the structureShow MoreRelatedDentistry Is A Old As History Of Humanity And Civilization1665 Words   |  7 Pagesmedicine that is as old as history of humanity and civilization. The earliest evidence was found back from the 7000 BC. Approximately 13,820 and 14,160 years old infected tooth from Italy which was cleaned with flint tools proves evidence of dentistry as oldest. Remains from Indus Valley Civilization show evidence of drilled teeth dating back 9000 years. Skulls of the Cro-Magnon people, who used to co lonize 25,000 years ago, show evidence of tooth decay. The earliest dental filling was discovered inRead More_x000C_Introduction to Statistics and Data Analysis355457 Words   |  1422 PagesBurgers 64 Activity 2.4 Video Games and Pain Management 65 Graphing Calculator Explorations 69 3 Graphical Methods for Describing Data 75 3.1 Displaying Categorical Data: Comparative Bar Charts and Pie Charts 76 3.2 Displaying Numerical Data: Stem-and-Leaf Displays 87 vii viii ââ€"   Contents 3.3 Displaying Numerical Data: Frequency Distributions and Histograms 97 3.4 Displaying Bivariate Numerical Data 117 3.5 Interpreting and Communicating the Results of Statistical Analyses 127Read MoreGsk Annual Report 2010135604 Words   |  543 Pagesour vaccine division is working now to develop immunotherapeutics aimed at educating the patient’s immune system to identify and attack cancer cells in a highly speciï ¬ c manner. Vaccine discovery involves many collaborations with academia and the biotech industry to identify new vaccine antigens which are then expressed in yeast, bacteria or mammalian cells and puriï ¬ ed to a very high level. This is followed by formulation of the clinical lots of the vaccine. This may involve mixing antigens with selectedRead MoreDamodaran Book on Investment Valuation, 2nd Edition398423 Words   |  1594 Pagesgive yourself a reasonable margin for error in making recommendations on the basis of valuations. The degree of precision in val uations is likely to vary widely across investments. The valuation of a large and mature company, with a long financial history, will usually be much more precise than the valuation of a young company, in a sector that is in turmoil. If this company happens to operate in an emerging market, with additional disagreement about the future of the market thrown into the mix, the